("Alliance" or "the Company") Exercise of Options

Alliance Pharma plc (AIM: APH), the speciality 
pharmaceutical company, announces that following 
the exercise of option on 7 December 2009, 
application has been made by Alliance for a 
further 57,625 ordinary shares of 1 pence each in 
the Company ("Ordinary Shares") to be admitted to 
trading AIM.

It is expected that these new Ordinary Shares, 
which will rank pari passu in all respects with 
the existing Ordinary Shares, will be admitted to 
trading on 11 December 2009.

Following the exercise of these options, Alliance 
will have 193,319,398 Ordinary Shares in issue.

For further information:

Alliance Pharma plc            + 44 (0) 1249 466966
John Dawson, Chief Executive
Richard Wright, Finance Director
www.alliancepharma.co.uk

Buchanan Communications        + 44 (0) 20 7466 5000
Mark Court / Stasa Filiplic / Jennie Spivey

Numis Securities Limited       + 44 (0) 20 7260 1000
Nominated Adviser: Michael Meade / Brent Nabb,
Corporate Broking: David Poutney / James Serjeant