Major Interest in Shares

Alliance Pharma plc (AIM: APH), the speciality pharmaceutical company, was informed on 22 May 2009 that Nigel Wray purchased, on 21 May 2009, a further 1,800,000 ordinary shares of 1p each in the Company. Mr Wray’s resultant shareholding is 16,669,995 ordinary shares, equivalent to 10.29% of the Company’s issued share capital.

Mr Wray’s ordinary shares are held as follows:

Nominee

Number of ordinary shares

Pershing Keen Nominees Limited                4,799,407

Smith & Williamson Nominees Limited             50,000

RBC Dexia London Account 22607            11,820,588

For further information:

Alliance Pharma plc                          +44 (0) 1249 466966
John Dawson, Chief Executive
Richard Wright, Finance Director
www.alliancepharma.co.ul

Buchanan Communications             +44 (0)20 7466 5000
Mark Court/Rebecca Skye Dietrich/Stasa Filiplic

Numis Securities Limited                  +44 (0)20 7260 1000
Nominated Adviser: Michael Meade/Brent Nabbs
Corporate Broking: David Poutney